109. Haruhiko Ninomiya1,19 · Naoshi Obara2,19 · Shigeru Chiba2,19 · Kensuke Usuki3,19 · Kaichi Nishiwaki4,19 · Itaru Matsumura5,19 · Tsutomu Shichishima6,19 · Shinichiro Okamoto7,19 · Jun‑ichi Nishimura8,19 · Kazuma Ohyashiki9,19 · Shinji Nakao10,19 · Kiyoshi Ando11,19 · Yoshinobu Kanda12,19 · Tatsuya Kawaguchi13,19 · Hideki Nakakuma14,19 · Daisuke Harada15 · Hirozumi Akiyama15 · Taroh Kinoshita16,19 · Keiya Ozawa17,19 · Mitsuhiro Omine18,19 · Yuzuru Kanakura8,19
Interim analysis of post‑marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan
Int J HematolInt J Hematol. 2016 Nov;104(5):548-558. Epub 2016 Jul 27.DOI 10.1007/s12185-016-2065-4
108. Miyasaka N, Miura O, Kawaguchi T, Arima N, Morishita E, Usuki K, Morita Y, Nishiwaki K, Ninomiya H, Gotoh A, Imashuku S, Urabe A, Shichishima T, Nishimura JI, Kanakura Y
Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review.
Int J Hematol. 2016 Jun;103(6):703-12. doi: 10.1007/s12185-016-1946-x. Epub 2016 Feb 8.
107. Kozuma Y1, Yamamoto T, Ishikawa E, Yoshida F, Akutsu H, Matsuda M, Nakai K, Tsuruta W, Takano S, Matsumura A, Ninomiya H.Sodium Bicarbonate Facilitates Hemostasis in the Presence of Cerebrospinal Fluid Through Amplification Platelet Aggregation.
Neurosurgery. 2016 Feb;78(2):274-84 2015 Oct 10. [Epub ahead of print]
106. Haruhiko Ninomiya, Naoshi Obara, Akiko Niiori-Onishi, Yokoyama Y, Sakata-Yanagimoto M, Hasegawa Y, Chiba S “Improvement of Renal Function by Long-Term Sustained Eculizumab Treatment in a Patient with Paroxysmal Nocturnal Hemoglobinuria,”
Case Reports in Hematology, vol. 2015, Article ID 673195, 4 pages, 2015. doi:10.1155/2015/673195
105. Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura JI, Kinoshita T, Bedrosian CL, Ozawa K, Omine M.Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial.
Int J Hematol. 2013 Oct 98(4): 406-416
104. Kurita N, Obara N, Fukuda K, Nishikii H, Sato S, Inagawa S, Kurokawa T, Owada Y, Ninomiya H, Chiba S.Blood Coagul Fibrinolysis. 2013 Sep;24(6):658-62.
103. Katsutani S, Tomiyama Y, Kimura A, Miyakawa Y, Okamoto S, Okoshi Y, Ninomiya H, Kosugi H, Ishii K, Ikeda Y, Hattori T, Katsura K, Kanakura : Oral eltrombopag for up to three years is safe and well-tolerated in Japanese patients with previously treated chronic immune thrombocytopenia: an open-label, extension study. Int J Hematol 98 (3): 323-30, 2013
102. Shirasugi Y, Ando K, Miyazaki K, Tomiyama Y, Iwato K, Okamoto S, Kurokawa M, Kirito K, Hshino S, Ninomiya H, Mori S, Yonemura Y, Usuki K, Wei H, Lizambri R. An open-label extension study evaluating the safety and efficacy of romiplostim for up to 3.5 years in thrombocytopenic Japanese patients with immune thrombocytopenic purpura (ITP). Int J Hematol 95: 652-659, 2012
101. Tomiyama Y, Miyakawa Y, Okamato S, Katsutani S, Kimura A, Okoshi Y, Ninomiya H, Kosugi H, Nomura S, Ozaki K, Ikeda Y, Hattori T, Katsura K, Kanakura Y. A lower starting dose of eltrombopag is efficacious in japanese patients with previously treated chronic immune thrombocytopenia (ITP). J Thromb Haemost. 2012 Mar 10: 799-806
100. Kusakabe M, Hasegawa Y, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, Takahashi S: c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver.Blood 118(5): 1374-85, 2011
99: Kozuma, Y., Sawahata, Y., Takei, Y., Chiba, S. & Ninomiya, H. :Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria. British Journal of Haematology, 2011 March, 152(5): 631-639, PubMed PMID: 21241275.
98: Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H , Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian CL, Valentine ME, Khursigara G, Ozawa K, Omine M:Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial. Int J Hematol, 2011 Jan, 93(1): 36-46, PubMed PMID: 21222185.
97: Kozuma Y, Ninomiya H, Murata S, Kono T, Mukai HY, Kojima H. The pro-apoptotic BH3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis. J Thromb Haemost. 2010 May;8(5):1088-97.Epub 2010 Jan 30. PubMed PMID: 20128868.
96: Ishigaki T, Sudo K, Hiroyama T, Miharada K, Ninomiya H, Chiba S, Nagasawa T,Nakamura Y. Human hematopoietic stem cells can survive in vitro for severalmonths. Adv Hematol. 2009;2009:936761. Epub 2008 Feb 8. PubMed PMID: 19960048;PubMed Central PMCID: PMC2778179.
95: Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H. Enhancedexpression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol. 2010 Feb;32(1 Pt 1):e137-43. Epub 2009 Mar 6. PubMed PMID: 19302232.
94: Kozuma Y, Yuki S, Ninomiya H, Nagasawa T, Kojima H. Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes. Leukemia. 2009 Jun;23(6):1080-6. Epub 2009 Feb 12. PubMed PMID: 19212331.
93: Kusakabe M, Suzukawa K, Nanmoku T, Obara N, Okoshi Y, Mukai HY, Hasegawa Y, Kojima H, Kawakami Y, Ninomiya H, Nagasawa T. Detection of the STAT5B-RARA fusion transcript in acute promyelocytic leukemia with the normal chromosome 17 on G-banding. Eur J Haematol. 2008 May;80(5):444-7. Epub 2008 Jan 23. PubMed PMID: 18221386.
92: Ninomiya H, Sato S, Hasegawa Y, Nagasawa T. Shortened lifespan of paroxysmal nocturnal haemoglobinuria-affected RBC estimated from differences in ratios of CD59-negative populations between reticulocytes and whole RBC. Int J Lab Hematol. 2008 Feb;30(1):41-5. PubMed PMID: 18190466.
91: Sato S, Hasegawa Y, Nagasawa T, Ninomiya H. Reticulocyte-gated flow cytometric analysis of red blood cells in paroxysmal nocturnal hemoglobinuria.Lab Hematol. 2006;12(2):82-5. PubMed PMID: 16751135.
90: Nishimura J, Kanakura Y, Ware RE, Shichishima T, Nakakuma H, Ninomiya H, Decastro CM, Hall S, Kanamaru A, Sullivan KM, Mizoguchi H, Omine M, Kinoshita T, Rosse WF. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore). 2004 May;83(3):193-207. PubMed PMID: 15118546.
89: Okoshi Y, Imagawa S, Higuchi M, Yoshida C, Shimizu S, Mukai HY, Komeno T, Hasegawa Y, Ninomiya H, Kojima H, Nagasawa T. A patient with acquired pure red cell aplasia showing a positive antiglobulin test and the presence of inhibitor against erythroid precursors. Intern Med. 2002 Jul;41(7):589-92. PubMed PMID: 12132531.
88: Urasaki T, Takasaki J, Nagasawa T, Ninomiya H. Pivotal role of 5-lipoxygenase in the activation of human eosinophils: platelet-activating factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway. J Leukoc Biol. 2001 Jan;69(1):105-12. PubMed PMID: 11200053.
87: Kojima H, Bai A, Mukai HY, Hori M, Komeno T, Hasegawa Y, Ninomiya H, Mori N, Nagasawa T. Chronic myelomonocytic leukemia derived from a possible common progenitor of monocytes and natural killer cells. Leuk Lymphoma. 2000 May;37(5-6):617-21. PubMed PMID: 11042523.
86: Kawashima Y, Nagasawa T, Ninomiya H. Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cells. Blood. 2000 Sep 15;96(6):2157-62. PubMed PMID: 10979961.
85: Ninomiya H, Kawashima Y, Nagasawa T. Inhibition of complement-mediated haemolysis in paroxysmal nocturnal haemoglobinuria by heparin or low-molecularweight heparin. Br J Haematol. 2000 Jun;109(4):875-81. PubMed PMID: 10929045.
84: Urasaki T, Takasaki J, Nagasawa T, Ninomiya H. Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipaseA2. Inflamm Res. 2000 Apr;49(4):177-83. PubMed PMID: 10858018.
83: Mukai HY, Kojima H, Suzukawa K, Hori M, Komeno T, Hasegawa Y, Ninomiya H, Mori N, Nagasawa T. Nasal natural killer cell lymphoma in a post-renal transplant patient. Transplantation. 2000 Apr 15;69(7):1501-3. PubMed PMID: 10798778.
82: Hasegawa Y, Bai A, Kojima H, Komeno T, Ninomiya H, Nagasawa T. Priming effects of macrophage colony-stimulating factor on monocytic leukemia cells in combination with chemotherapy: induction of programmed cell death in vivo. Leuk Lymphoma. 2000 Feb;36(5-6):589-93. PubMed PMID: 10784404.
81: Obara N, Ohkoshi Y, Mukai HY, Komeno T, Hasegawa Y, Kojima H, Ninomiya H, Nagasawa T. [T-cell prolymphocytic leukemia with CD4+8+25+ phenotype in a patient presenting with venous thrombosis in the lower leg]. Rinsho Ketsueki. 1999Nov;40(11):1187-92. Japanese. PubMed PMID: 10624130.
80: Hasegawa Y, Itoh T, Tamagawa Y, Komeno T, Kojima H, Ninomiya H, Yatabe Y, Mori N, Nagasawa T. Non-Hodgkin's lymphoma followed by plasmacytoma, both arising in A thyroid gland with Hashimoto's disease. Leuk Lymphoma. 1999 Nov;35(5-6):613-8. PubMed PMID: 10609800.
79: Obara N, Shinagawa A, Komatsu T, Abe T, Ninomiya H. Derivative (1;7)(q10;p10) in a patient with de novo acute erythroblastic leukemia (AML-M6). Cancer Genet Cytogenet. 1999 Nov;115(1):62-4. PubMed PMID: 10565302.
78: Ninomiya H. [Diagnosis and therapy of megaloblastic anemia]. Nippon Naika Gakkai Zasshi. 1999 Jun 10;88(6):980-5. Review. Japanese. PubMed PMID: 10465938.
77: Ninomiya H, Kawashima Y, Hasegawa Y, Nagasawa T. Complement-induced procoagulant alteration of red blood cell membranes with microvesicle formation in paroxysmal nocturnal haemoglobinuria (PNH): implication for thrombogenesis in PNH. Br J Haematol. 1999 Jul;106(1):224-31. PubMed PMID: 10444191.
76: Ohkoshi Y, Ninomiya H, Mukai HY, Mochizuki N, Hori M, Nagasawa T, Jikuya T, Saida Y. Pseudoaneurysm of the subclavian artery due to Xanthomonas pneumonia in a patient with acute myeloid leukemia: its rupture treated by transcatheter coil embolization. Intern Med. 1999 Aug;38(8):671-4. PubMed PMID: 10440506.
75: Mukai HY, Kojima H, Suzukawa K, Hori M, Komeno T, Hasegawa Y, Ninomiya H, Mori N, Nagasawa T. High-dose chemotherapy with peripheral blood stem cell rescue in blastoid natural killer cell lymphoma. Leuk Lymphoma. 1999 Feb;32(5-6):583-8. PubMed PMID: 10048432.
74: Bai A, Kojima H, Hori M, Nara N, Komeno T, Hasegawa Y, Ninomiya H, Abe T, Nagasawa T. Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells. Exp Hematol. 1999 Feb;27(2):259-65. PubMed PMID: 10029165.
73: Urasaki T, Ninomiya H, Takasaki J, Kawauchi Y, Nagasawa T, Masuho Y. Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. Inflamm Res. 1999 Jan;48(1):36-40. PubMed PMID: 9987681.
72: Shinagawa A, Komatsu T, Ninomiya H. Complex translocation (6;21;8), a variant of t(8;21), with trisomy 4 in a patient with acute myelogenous leukemia (M2). Cancer Genet Cytogenet. 1999 Feb;109(1):72-5. PubMed PMID: 9973964.
71: Osada M, Komeno T, Todokoro K, Takizawa M, Kojima H, Suzukawa K, Ninomiya H, Abe T, Nagasawa T. Immature megakaryocytes undergo apoptosis in the absence of thrombopoietin. Exp Hematol. 1999 Jan;27(1):131-8. PubMed PMID: 9923451.
70: Suzukawa K, Kojima H, Mori N, Mukai HY, Hori M, Komeno T, Hasegawa Y, Ninomiya H, Nagasawa T. Anaplastic large-cell lymphoma of null-cell type with multiple bone involvement. Ann Hematol. 1998 Dec;77(6):287-90. Review. PubMed PMID: 9875667.
69: Nagasawa T, Hasegawa Y, Shimizu S, Kawashima Y, Nishimura S, Suzukawa K, Mukai H, Hori M, Komeno T, Kojima H, Ninomiya H, Tahara T, Abe T. Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects. Br J Haematol. 1998 May;101(2):242-4. PubMed PMID: 9609516.
68: Mukai HY, Ninomiya H, Nagasawa T, Abe T. Elevated serum levels of eosinophil major basic protein in patients with myeloproliferative disorders without eosinophilia. Int J Hematol. 1997 Aug;66(2):197-202. PubMed PMID: 9277050.
67: Hasegawa Y, Ninomiya H, Kamoshita M, Ohtani K, Kobayashi T, Kojima H, Nagasawa T, Abe T. Interstitial pneumonitis related to granulocytecolony-stimulating factor administration following chemotherapy for elderly patients with non-Hodgkin's lymphoma. Intern Med. 1997 May;36(5):360-4. PubMed PMID: 9213175.
66: Ninomiya H, Hasegawa Y, Nagasawa T, Abe T. Excess soluble urokinase-type plasminogen activator receptor in the plasma of patients with paroxysmal nocturnal hemoglobinuria inhibits cell-associated fibrinolytic activity. Int J Hematol. 1997 Apr;65(3):285-91. PubMed PMID: 9114600.
65: Shinagawa A, Itoh T, Komeno T, Komatsu T, Hasegawa Y, Kobayashi T, Kozima H, Ninomiya H, Nagasawa T, Abe T. [Allopurinol induced pancytopenia in a patient with myeloproliferative disorder]. Rinsho Ketsueki. 1997 Jan;38(1):64-71. Japanese. PubMed PMID: 9028164.
64: Mukai HY, Kojima H, Todokoro K, Tahara T, Kato T, Hasegawa Y, Kobayashi T, Ninomiya H, Nagasawa T, Abe T. Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thromb Haemost. 1996 Nov;76(5):675-8. PubMed PMID: 8950771.
63: Komeno T, Ninomiya H, Itoh T, Fujita T, Nagasawa T, Abe T. Hemolytic anemia associated with myotonic muscular dystrophy. Intern Med. 1996 Sep;35(9):746-8. PubMed PMID: 8915705.
62: Hasegawa A, Ninomiya H, Yanagisawa K, Takada K, Hasegawa H, Hato T, Yasukawa M, Fujita S. [Successful treatment of combined interferon-alpha and hydroxycarbamide for chronic myelogenous leukemia following therapy for malignant lymphoma]. Rinsho Ketsueki. 1996 Sep;37(9):853-7. Japanese. PubMed PMID: 8914475.
61: Mukai HY, Ninomiya H, Mitsuhashi S, Hasegawa Y, Nagasawa T, Abe T. Thromboembolism in a patient with transient eosinophilia. Ann Hematol. 1996 Feb;72(2):93-5. PubMed PMID: 8597615.
60: Kobayashi T, Nagasawa T, Mitsuhashi S, Hasegawa Y, Kojima H, Ninomiya H, Mori N, Abe T. Clinicopathological characteristics of primary Ki-1 anaplastic large cell lymphoma. Int J Hematol. 1996 Jan;63(1):41-50. PubMed PMID: 8713576.
59: Ito T, Kojima H, Otani K, Komeno T, Mitsuhashi S, Hasegawa Y, Kobayashi T, Ninomiya H, Nagasawa T, Abe T. Chronic neutrophilic leukemia associated with monoclonal gammopathy of undetermined significance. Acta Haematol. 1996;95(2):140-3. Review. PubMed PMID: 8638444.
58: Komeno T, Ninomiya H, Itoh T, Hasegawa Y, Kobayashi T, Mori N, Nagasawa T, Abe T. CD34-positive blastoma in a patient with idiopathic myelofibrosis. Intern Med. 1995 Oct;34(10):1035-7. PubMed PMID: 8563086.
57: Koike T, Enokihara H, Arimura H, Ninomiya H, Yamashiro K, Tsuruoka N, Tsujimoto M, Aoyagi M, Watanabe K, Nakamura Y, et al. Serum concentrations of IL-5, GM-CSF, and IL-3 and the production by lymphocytes in various eosinophilia. Am J Hematol. 1995 Oct;50(2):98-102. PubMed PMID: 7573007.
56: Hasegawa Y, Nagasawa T, Kamoshita M, Komeno T, Itoh T, Ninomiya H, Abe T. Effects of anti-platelet glycoprotein Ib and/or IIb/IIIa autoantibodies on the size of megakaryocytes in patients with immune thrombocytopenia. Eur J Haematol. 1995 Sep;55(3):152-7. PubMed PMID: 7672087.
55: Nagasawa T, Hasegawa Y, Kamoshita M, Ohtani K, Komeno T, Itoh T, Shinagawa A, Kojima H, Ninomiya H, Abe T. Megakaryopoiesis in patients with cyclic thrombocytopenia. Br J Haematol. 1995 Sep;91(1):185-90. PubMed PMID: 7577630.
54: Ohtani K, Ninomiya H, Hasegawa Y, Kobayashi T, Kojima H, Nagasawa T, Abe T. Clinical significance of elevated soluble interleukin-6 receptor levels in the sera of patients with plasma cell dyscrasias. Br J Haematol. 1995 Sep;91(1):116-20. PubMed PMID: 7577617.
53: Mukai HY, Ninomiya H, Ohtani K, Nagasawa T, Abe T. Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Br J Haematol. 1995 Aug;90(4):892-9. PubMed PMID: 7669668.
52: Kojima H, Komeno T, Shinagawa A, Hasegawa Y, Kobayashi T, Ninomiya H, Nagasawa T, Abe T. CD3+, CD56+ large granular lymphocyte leukemia. Blood. 1995 Jun 15;85(12):3762. PubMed PMID: 7540072.
51: Nagasawa T, Hasegawa Y, Komeno T, Itoh T, Ninomiya H, Abe T. Simultaneous measurements of megakaryocyte-associated IgG (MAIgG) and platelet-associated IgG (PAIgG) in chronic idiopathic thrombocytopenic purpura. Eur J Haematol. 1995 May;54(5):314-20. PubMed PMID: 7781756.
50: Mitsuhashi S, Nagasawa T, Kamoshita M, Otani K, Hasegawa Y, Kojima H, Ninomiya H, Nakazawa M, Abe T. [Minimally differentiated hypoplastic leukemia]. Rinsho Ketsueki. 1995 Feb;36(2):115-20. Japanese. PubMed PMID: 7715082.
49: Kamoshita M, Suzukawa K, Kobayashi T, Hasegawa Y, Satoh Y, Ninomiya H, Nagasawa T, Abe T. [von Recklinghausen's disease complicated by macroglobulinemia, malignant schwannoma and pheochromocytoma]. Rinsho Ketsueki. 1995 Jan;36(1):59-62. Japanese. PubMed PMID: 7715079.
48: Ninomiya H. [Clinical features and diagnosis of paroxysmal nocturnal hemoglobinuria: correlates with the deficiency of GPI-anchored membrane proteins]. Rinsho Ketsueki. 1994 Apr;35(4):352-7. Japanese. PubMed PMID: 7518013.
47: Yamamoto H, Ninomiya H, Yoshimatsu K, Uchiyama Y, Shibasaki M, Enokihara H, Tachibana S, Abe T. Serum levels of major basic protein in patients with or without eosinophilia: measurement by enzyme-linked immunosorbent assay. Br J Haematol. 1994 Mar;86(3):490-5. PubMed PMID: 8043431.
46: Mitsuhashi S, Ninomiya H, Shibuya A, Kojima H, Nagasawa T, Ohsaka A, Watanabe T, Kawachi S, Watanabe N, Ishida H, et al. [Effect of THP-CVP regimen for elderly patients with malignant lymphoma]. Rinsho Ketsueki. 1993 Dec;34(12):1532-9. Japanese. PubMed PMID: 8295326.
45: Sato Y, Mituhashi S, Otani K, Kamoshita M, Hasegawa Y, Ninomiya H, Nagasawa T, Abe T. [A study of hypoplastic myelodysplastic syndrome]. Rinsho Ketsueki. 1993 Nov;34(11):1431-7. Japanese. PubMed PMID: 8254904.
44: Suzukawa K, Ninomiya H, Mitsuhashi S, Anno I, Nagasawa T, Abe T. Demonstration of the deposition of hemosiderin in the kidneys of patients with paroxysmal nocturnal hemoglobinuria by magnetic resonance imaging. Intern Med. 1993 Sep;32(9):686-90. PubMed PMID: 8142671.
43: Shibuya K, Ninomiya H, Muraki Y, Nagasawa T, Abe T. Deficiency of glycosyl phosphatidylinositol-anchored proteins in polymorphonuclear leukocytes from patients with paroxysmal nocturnal hemoglobinuria with low-grade hemolysis. Int J Hematol. 1993 Aug;58(1-2):15-20. PubMed PMID: 7693026.
42: Ninomiya H, Muraki Y, Shibuya K, Nagasawa T, Abe T. Induction of Fc gamma R-III (CD16) expression on neutrophils affected by paroxysmal nocturnal haemoglobinuria by administration of granulocyte colony-stimulating factor. Br J Haematol. 1993 Jul;84(3):497-503. PubMed PMID: 7692930.
41: Kamoshita M, Ohtani K, Hasegawa Y, Satoh Y, Kozima H, Shibuya A, Ninomiya H, Nagasawa T, Matsunaga Y, Abe T. [Human parvovirus B19-induced aplastic crisis in an elderly man with intestinal hemorrhage]. Rinsho Ketsueki. 1993 Apr;34(4):493-5. Japanese. PubMed PMID: 8510339.
40: Hasegawa Y, Nagasawa T, Kojima H, Shibuya A, Ninomiya H, Abe T. [Treatment of elderly patients with chronic idiopathic thrombocytopenic purpura]. Rinsho Ketsueki. 1993 Apr;34(4):460-4. Japanese. PubMed PMID: 8510334.
39: Braga LL, Ninomiya H, McCoy JJ, Eacker S, Wiedmer T, Pham C, Wood S, Sims PJ, Petri WA Jr. Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica. J Clin Invest. 1992 Sep;90(3):1131-7. PubMed PMID: 1381719; PubMed Central PMCID: PMC329975.
38: Ninomiya H, Sims PJ. The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9. J Biol Chem. 1992 Jul 5;267(19):13675-80. PubMed PMID: 1377690.
37: Ninomiya H, Stewart BH, Rollins SA, Zhao J, Bothwell AL, Sims PJ. Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity. J Biol Chem. 1992 Apr 25;267(12):8404-10. PubMed PMID: 1373727.
36: Kobayashi T, Nakazawa M, Sato Y, Tomiyama J, Ninomiya H, Abe T, Terasawa T, Shichishima T, Fujita T. [Immunocytochemical staining of decay-accelerating factor (DAF) on erythrocytes: paroxysmal nocturnal hemoglobinuria (PNH)]. Rinsho Ketsueki. 1992 Feb;33(2):162-6. Japanese. PubMed PMID: 1378912.
35: Braga LL, Ninomiya H, McCoy JJ, Adal K, Wiedmer T, Pham C, Sims PJ, Petri WA Jr. Inhibition of the complement membrane attack complex by thegalactose-specific adhesin of Entamoeba histolytica. Arch Med Res. 1992;23(2):133. PubMed PMID: 1340275.
34: Ninomiya H, Kobayashi T, Abe T. [Paroxysmal nocturnal hemoglobinuria (PNH) deficiency of major complement-regulatory membrane proteins on erythrocytes]. Rinsho Ketsueki. 1991 Jun;32(6):612-7. Japanese. PubMed PMID: 1716325.
33: Rollins SA, Zhao J, Ninomiya H, Sims PJ. Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9. J Immunol. 1991 Apr 1;146(7):2345-51. PubMed PMID: 1706395.
32: Abe T, Ninomiya H. [Paroxysmal nocturnal hemoglobinuria]. Nippon Rinsho.1991 Mar;49(3):667-71. Japanese. PubMed PMID: 1828276.
31: Tomiyama J, Ninomiya H, Abe T. Enhanced complement-susceptibility and dysfunction of lymphocytes in paroxysmal nocturnal haemoglobinuria (PNH). Br J Haematol. 1990 Dec;76(4):540-4. PubMed PMID: 1702310.
30: Suzuki T, Koizumi J, Arinami T, Shiraishi H, Ofuku K, Kawai N, Baba A, Ninomiya H. Neuropsychiatric disturbances in a patient with a nonmosaic isodicentric (X) (q21.32) chromosome. Jpn J Psychiatry Neurol. 1990 Sep;44(3):563-70. PubMed PMID: 2127433.
29: Kawakami Z, Ninomiya H, Tomiyama J, Abe T. Deficiency of glycosyl-phosphatidylinositol anchored proteins on paroxysmal nocturnal haemoglobinuria (PNH) neutrophils and monocytes: heterogeneous deficiency of decay-accelerating factor (DAF) and CD16 on PNH neutrophils. Br J Haematol. 1990 Apr;74(4):508-13. PubMed PMID: 1693286.
28: Hasegawa Y, Sakai N, Toyama M, Ninomiya H, Abe T. [Chronic myelomonocytic leukemia transformed from refractory anemia with ring sideroblasts with a rare abnormal chromosome, inv (12)]. Rinsho Ketsueki. 1990 Jan;31(1):75-9. Review. Japanese. PubMed PMID: 2179602.
27: Ninomiya H, Abe T, Fujita T. Prolongation of red-cell life-span by incorporation of decay-accelerating factor (DAF) into red cells of paroxysmal nocturnal haemoglobinuria (PNH). Br J Haematol. 1989 Sep;73(1):132-3. PubMed PMID: 2478184.
26: Hasegawa Y, Tomiyama J, Ninomiya H, Abe T. [Appearance of Sweet's syndrome in a patient with myelodysplastic syndrome (MDS) without relation to the hematological findings of MDS]. Rinsho Ketsueki. 1989 Jun;30(6):863-7. Japanese. PubMed PMID: 2795896.
25: Tomiyama J, Ninomiya H, Nakazawa M, Nagasawa T, Yoda Y, Abe T. [Dysfunction and deficiency of decay-accelerating factor (DAF) demonstrated in the lymphocytes from a patient with paroxysmal nocturnal hemoglobinuria (PNH)]. Rinsho Ketsueki. 1989 Jun;30(6):845-9. Japanese. PubMed PMID: 2477566.
24: Shibuya A, Ninomiya H, Nakazawa M, Nagasawa T, Yoda Y, Abe T. Oxymetholone therapy in patients with familial antithrombin III deficiency. Thromb Haemost. 1988 Dec 22;60(3):495-7. PubMed PMID: 3238652.
23: Tsuda A, Rin KY, Toyama K, Ninomiya H, Abe T. [Acute thrombocytopenic purpura in a case of paroxysmal nocturnal hemoglobinuria]. Rinsho Ketsueki. 1988 Dec;29(12):2384-5. Japanese. PubMed PMID: 3246724.
22: Tomiyama J, Sato Y, Kobayashi T, Shibuya A, Ninomiya H, Nagasawa T, Yoda Y, Abe T. [Transformation of ALL to acute mixed leukemia]. Rinsho Ketsueki. 1988 Nov;29(11):2121-6. Japanese. PubMed PMID: 3236420.
21: Ninomiya H, Abe T, Shichishima T, Terasawa T, Fujita T. Decay-accelerating factor (DAF) on the blood cell membranes in patients with paroxysmal nocturnal haemoglobinuria (PNH): measurement by enzyme-linked immunosorbent assay (ELISA). Br J Haematol. 1988 May;69(1):81-7. PubMed PMID: 2454648.
20: Ohse H, Nagasawa T, Ninomiya H, Shibuya A, Nakazawa M, Yoda Y, Abe T. [Acute mixed leukemia (AMixL) with both myeloid and lymphoid phenotypes: selection of treatment for AMixL]. Rinsho Ketsueki. 1988 Apr;29(4):577-83. Review. Japanese. PubMed PMID: 3043042.
19: Ninomiya H, Tomiyama J, Imagawa S, Shibuya A, Hanada T, Kageoka T, Nagasawa T, Yoda Y, Abe T, Fujita T. [Recurrence of thromboses and infections in a patient with paroxysmal nocturnal hemoglobinuria (PNH)]. Rinsho Ketsueki. 1988 Jan;29(1):54-8. Japanese. PubMed PMID: 2455076.
18: Shibuya A, Ninomiya H, Nakazawa M, Nagasawa T, Yoda Y, Abe T. [Congenital antithrombin III (ATIII) deficiency with thrombosis of superior sagittal sinus and of inferior vena cava]. Rinsho Ketsueki. 1987 Nov;28(11):2000-3. Japanese. PubMed PMID: 3446871.
17: Kobayashi T, Hanada T, Sato Y, Shibuya A, Ninomiya H, Nagasawa T, Abe T. [A case of pure red cell aplasia with monoclonal gammopathy: immune-mediated inhibition of erythropoiesis]. Rinsho Ketsueki. 1987 Nov;28(11):2029-33. Japanese. PubMed PMID: 3128675.
16: Nakazawa M, Ninomiya H, Nagasawa T, Abe T. Factor XIII A-chain in neoplastic proliferation of megakaryoblasts--a comparison with von Willebrand factor antigen. Nippon Ketsueki Gakkai Zasshi. 1987 Sep;50(6):1246-53. PubMed PMID: 3500566.
15: Ninomiya H, Hanada T, Nakazawa M, Aoki Y, Shibuya A, Nagasawa T, Abe T. Immunological erythroblastopenia induced by HCO-60 as a solvent of enocitabine (BH-AC). Nippon Ketsueki Gakkai Zasshi. 1987 Jul;50(4):777-83. PubMed PMID: 3120451.
14: Shibuya A, Ninomiya H, Nakazawa M, Kageoka T, Yoda Y. [A study of the incidence of ATL (adult T-cell leukemia) and anti-ATLA (antibody to the ATL-associated antigen) in an ATL-non-endemic area]. Rinsho Ketsueki. 1987 Jun;28(6):852-6. Japanese. PubMed PMID: 2889837.
13: Aoki Y, Shibuya A, Ninomiya H, Nakazawa M, Nakamura H, Kageoka T, Nagasawa T, Yoda Y, Abe T. [Cerebellar infarction following remission induction therapy in acute lymphoblastic leukemia]. Rinsho Ketsueki. 1987 Apr;28(4):624-8. Japanese. PubMed PMID: 3476768.
12: Nagasawa T, Nakazawa M, Ninomiya H, Abe T. A cell kinetic study of megakaryoblastic progenitors during establishing megakaryoblastic cell line. Keio J Med. 1987 Jan;36(1):81-2. PubMed PMID: 3613393.
11: Ninomiya H, Nakazawa M, Aoki Y, Nakamura H, Abe T. [Clinical features of phagocytic plasma cell myeloma]. Rinsho Ketsueki. 1986 Dec;27(12):2309-12. Japanese. PubMed PMID: 3573321.
10: Ninomiya H, Yoda Y, Shibuya A, Nakazawa M, Nagasawa T, Abe T, Mori N, Komiyama A. [Abnormal expansion of azurophilic granular lymphocytes with peculiar surface phenotype in a case of malignant lymphoma]. Rinsho Ketsueki. 1986 Nov;27(11):2168-72. Japanese. PubMed PMID: 2434689.
9: Ninomiya H, Nagasawa T, Aoki Y, Abe T, Okuyama A, Saito K, Furusawa S. Treatment of autoimmune neutropenia with intravenous high-dose gammaglobulin. Nippon Ketsueki Gakkai Zasshi. 1986 Sep;49(6):1175-80. PubMed PMID: 3811784.
8: Shibuya A, Kageoka T, Ninomiya H, Aoki Y, Nakazawa M, Hanada T, Abe T. Transmission of HTLV-1 by blood transfusion in an ATL-non-endemic area. Nippon Ketsueki Gakkai Zasshi. 1986 Sep;49(6):1206-11. PubMed PMID: 2880445.
7: Nakazawa M, Ninomiya H, Abe T, Mori N, Kojima M. Morphological and functional studies of myeloma cells with haemophagocytosis. Nippon Ketsueki Gakkai Zasshi. 1986 Jul;49(4):938-49. PubMed PMID: 3490106.
6: Hanada T, Aoki Y, Ninomiya H, Abe T. T cell-mediated inhibition of haematopoiesis in aplastic anaemia: serial assay of inhibitory activities of T cells to autologous CFU-E during immunosuppressive therapy. Br J Haematol. 1986 May;63(1):69-74. PubMed PMID: 3486672.
5: Nakazawa M, Ninomiya H, Aoki Y, Hanada T, Nagasawa T, Mori N, Yoda Y, Abe T. Identification of neoplastically proliferating megakaryoblasts. Nippon Ketsueki Gakkai Zasshi. 1986 Feb;49(1):115-26. PubMed PMID: 3458350.
4: Ninomiya H, Nakazawa M, Shibuya A, Aoki Y, Nagasawa T, Abe T. Successful treatment of acute megakaryoblastic leukaemia. Scand J Haematol. 1986 Feb;36(2):147-53. PubMed PMID: 3458290.
3: Imagawa S, Aoki Y, Ninomiya H, Yoda Y, Abe T. Beta-2-microglobulin concentration in cerebrospinal fluid--monitoring of malignant lymphoma in the central nervous system. Nippon Ketsueki Gakkai Zasshi. 1985 Jul;48(4):1059-64. PubMed PMID: 3904291.
2: Imagawa S, Ninomiya H, Wang ZB, Nakazawa M, Nakamura H, Yoda Y, Ohno A. [A case of IgG-Bence Jones protein kappa type multiple myeloma complicated by adult Fanconi syndrome and osteomalacia]. Rinsho Ketsueki. 1984 Jan;25(1):69-74. Japanese. PubMed PMID: 6431148.
1: Yamane K, Ninomiya H, Shabana M, Kono I, Kabashima T, Sakurai T, Kashiwagi H. Eosinophilic fasciitis with prominent immunologic abnormalities. Jpn J Med. 1983 Apr;22(2):134-6. PubMed PMID: 6865106.
研究テーマ
(C) 2000-2018 Ninomiya-H
